L-arginine-induced experimental pancreatitis

L-arginine-induced experimental acute pancreatitis

Different animal models of experimental acute pancreatitis induced by caerulein, choline deficient ethionine supplemented (CDE) diet, or sodium taurocholate have been developed. These models vary in severity and have been used by the investigators to either understand the pathophysiological mechanism of the disease or to study the effect of different therapeutic agents. Mizunuma et al (18) were...

Cellular Mechanisms of L- arginine Induced Experimental Acute Pancreatitis

Intravenous selenium modulates L-arginine-induced experimental acute pancreatitis.

CONTEXT Oxidative stress is understood to have a critical role in the development of acinar injury in experimental acute pancreatitis. We have previously demonstrated that compound multiple antioxidant therapy ameliorates end-organ damage in the intra-peritoneal L-arginine rat model. As the principal co-factor for glutathione, selenium is a key constituent of multiple antioxidant preparations. ...

Prophylactic Administration of Silybin Ameliorates L-Arginine-Induced Acute Pancreatitis

BACKGROUND Oxidative stress have been shown to play a role in the pathogenesis of acute pancreatitis. The aim of this study was to investigate the potential effect of silybin, a potent antioxidant, on L-arginine-induced acute pancreatitis in an experimental rat model. MATERIAL AND METHODS Forty female Wistar Albino rats were divided into 5 groups as follows: Group 1 (C): control group (n=8), Gr...

Effects of trimetazidine in acute pancreatitis induced by L-arginine.

BACKGROUND In acute pancreatitis, oxygen free radicals (OFRs) and cytokines have been shown to play a role in the failure of pancreatic microcirculation and the development of local tissue damage. We studied the effects of trimetazidine (TMZ), a potent antioxidant and anti-ischemic agent, on acute pancreatitis. METHODS Rats were randomized into 3 groups: a control group (n = 15), a study grou...